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Zuplenz Side Effects

If you are taking Zuplenz, you may develop side effects such as constipation, headaches, and diarrhea. In most cases, these reactions are minor and easy to treat. However, it is possible to experience potentially serious side effects. Contact your healthcare provider right away if you have an irregular heart rhythm, an unexplained rash, or difficulty breathing.

An Introduction to Zuplenz Side Effects

As with any medicine, Zuplenz™ (Ondansetron Oral Soluble Film) can cause side effects. However, not everyone who uses the medication will have problems. Most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the potential side effects of this medication. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Zuplenz

Zuplenz was approved by the United States Food and Drug Administration (FDA) based on the safety and efficacy of Zofran®, the tablet form of ondansetron. Therefore, the information on potential side effects for Zuplenz is actually taken directly from studies of Zofran tablets, not from studies of Zuplenz specifically.
Zofran has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking Zofran were documented and then compared to the side effects that occurred in a similar group of people taking a placebo (a "sugar pill" that does not contain any active ingredients).
In these studies, the most common Zofran side effects included:
  • Headaches -- occurring in up to 27 percent of people
  • Tiredness (fatigue) or a general ill feeling -- in up to 13 percent
  • Constipation -- in up to 9 percent (see Zofran and Constipation)
  • Low oxygen levels (when used for surgery) -- in up to 9 percent
  • Fever -- in up to 8 percent.
Other common side effects (occurring in 5 to 7 percent of people) included:
  • Diarrhea
  • Gynecological disorders (problems with the female reproductive system)
  • Anxiety or agitation
  • Difficulty emptying the bladder (urinary retention)
  • Itching
  • Dizziness.
Zuplenz works by blocking serotonin receptors. Serotonin is a chemical that is also important in depression. However, Zuplenz works on different receptors than those that are related to depression, which explains why depression is not a side effect of Zuplenz.
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Zuplenz Medication Information

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