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Zometa Warnings and Precautions

If you have kidney or liver disease, asthma, or any allergies, let your healthcare provider know before you take Zometa. Warnings and precautions also include avoiding the drug if you are pregnant, watching out for potential drug interactions, and monitoring your kidney function closely during treatment. You should also avoid taking Zometa if you are allergic to any active or inactive components of the medication.

Zometa: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Zometa® (zoledronic acid) if you have:
  • Kidney disease, including kidney failure (renal failure)
  • Liver disease, such as liver failure, cirrhosis, or hepatitis
  • Asthma
  • Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding
  • Planning to have a dental procedure.
Make sure to tell your healthcare provider about all other medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Zometa

Warnings and precautions to be aware of prior to taking Zometa include the following:
  • Zometa can cause kidney damage. In order to decrease this risk, your Zometa dose should be given by IV over at least a 15-minute period; giving it more quickly can damage the kidneys. Your healthcare provider should monitor your kidney function closely, using a simple blood test before each Zometa dosage. If your kidney function is declining, you may need a lower dose, or you may need to postpone your dose until your kidney function improves. If you already have kidney disease, Zometa may not be a good choice for you.
  • In rare cases, bisphosphonates (such as Zometa) have caused a condition called osteonecrosis of the jaw. This is a serious, possibly disfiguring problem in which the bone of the jaw dies. Often, there are symptoms (such as pain, infection, or loosening of the teeth), but sometimes there are no symptoms until a person notices exposed bone. This problem is most common when bisphosphonates are given by IV. It seems that people who have dental procedures (such as a tooth extraction) are also at higher risk. Be sure to take good care of your mouth and teeth by seeing your dentist frequently. Let your healthcare provider know right away if you think you may have osteonecrosis of the jaw.


  • There have been rare reports of unusual broken thigh bones in people taking bisphosphonate medications (like Zometa). It is not yet clear if the medications are to blame, since the fractures could simply be due to the underlying disease processes or other factors. These fractures typically were not caused by trauma or injury. Let your healthcare provider know if you have unexplained groin or thigh pain, as these are sometimes signs of thigh fractures. 


  • Zometa can cause low blood calcium, phosphate, and magnesium. Your healthcare provider should monitor you closely for these problems.
  • Other bisphosphonates are known to cause problems in people with aspirin-sensitive asthma. Let your healthcare provider know if Zometa seems to make your asthma worse.
  • Bisphosphonates (including Zometa) can cause extreme muscle or bone pain. This usually goes away once the medication is stopped.
  • Zometa can potentially interact with a few other medications (see Zometa Drug Interactions).
  • Zometa is considered a pregnancy Category D medication. This means that it is probably not safe for use during pregnancy (see Zometa and Pregnancy).
  • It is not known whether Zometa passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Zometa and Breastfeeding).
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