Zofran

A healthcare provider may prescribe Zofran to prevent nausea and vomiting associated with chemotherapy, radiation therapy for cancer, or surgery. The drug works by blocking your body's production of serotonin, a chemical that is associated with nausea and vomiting. Zofran comes in several forms and your dose will depend on a number of factors, including your age and the medical condition you are being treated for. There are some potential side effects of Zofran, including headaches, fatigue, and constipation.

 

What Is Zofran?

Zofran® (ondansetron hydrochloride) is a prescription medicine that has been licensed to prevent nausea and vomiting due to several causes.
 

Who Makes Zofran?

Zofran is manufactured by GlaxoSmithKline.
 

What Is Zofran Used For?

Uses of Zofran include:
 
  • Prevention of nausea and vomiting associated with chemotherapy
  • Prevention of nausea and vomiting due to radiation therapy for cancer
  • Prevention of postoperative nausea and vomiting that can occur after surgery.
     
Zofran is not intended to treat nausea or vomiting that is already occurring.
 
(Click Zofran Uses for more information on what Zofran is used for, including possible off-label uses.)
 

How Does Zofran Work?

Nausea (upset stomach) and vomiting are complex processes involving many chemicals in the body and several parts of the body, including the brain and the small intestine. It is likely that Zofran works in the small intestine, but Zofran may also work in the brain. Zofran works by blocking serotonin, a chemical produced by the body that is associated with nausea and vomiting. Serotonin has many effects in the body and has several receptors where it can bind. Zofran blocks serotonin at a specific type of receptor (the 5-HT3 receptor).
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;