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Zofran Side Effects

Side Effects to Report

There are a number of side effects with Zofran that you should report immediately to your healthcare provider. These include, but are not limited to:
  • Chest pain
  • Unexplained skin rash
  • Itching
  • Hives
  • Unexplained swelling
  • Wheezing
  • Difficulty breathing or swallowing
  • Unsteady or shaky movements
  • Tremors.

Rare Zofran Side Effects

There are other Zofran side effects that can occur. These side effects happen in very few patients taking Zofran. For these side effects, it is difficult to tell whether the side effect is caused by the Zofran or something else.
Some of these rare Zofran side effects include, but are not limited to:
  • Shakiness, tremors, or unusually stiff muscles
  • Increased liver enzymes (found using a blood test)
  • Increased heart rate (tachycardia)
  • Chest pain
  • Changes in heart rhythm (especially an arrhythmia called QT prolongation)
  • Flushing (redness of the skin, especially the face)
  • Hiccups
  • Spasms of muscles of the eye, causing the eyes to become fixed in a certain position, often staring upward
  • Temporary blindness.

Final Thoughts

You may experience some or none of the Zofran side effects explained above. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have side effects from a medicine that you have never tried. Therefore, be sure to let your healthcare provider know if you develop any side effects. Also, let your healthcare provider know if you develop something that "just does not seem right." While it may not be a side effect of Zofran, your healthcare provider will be able to diagnose and treat the problem.
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