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Zofran Sexual Side Effects

Based on clinical studies, sexual side effects, such as impotence or a decrease in sex drive, were not reported as either a common or rare side effect with Zofran. However, once a medication is approved, it is not usually studied anymore. As a result, certain side effects that occur very rarely may never be documented, especially if it is not a serious side effect. Therefore, be sure to talk to your healthcare provider if you develop any Zofran sexual side effects.

An Overview Zofran Sexual Side Effects

Zofran® (ondansetron hydrochloride) is a prescription medication that has been licensed to prevent nausea and vomiting associated with chemotherapy, radiation, and surgery. As with all medicines, Zofran has possible side effects. In clinical studies prior to the approval of Zofran, there were no reported sexual side effects. Since Zofran was approved, sexual problems also have not been reported.
 

Understanding Clinical Trials

Before medicines are approved, they must go through several clinical studies where thousands of people are given a particular medicine and are then compared to a group of people not given the medicine. In these studies, side effects are always documented. As a result, it is possible to see which side effects occur, how often they appear, and how they compare to the group not taking the medicine. Side effects are then usually separated into those side effects that occur in more than 1 percent of people and those that occur in less than 1 percent of people. Sexual side effects, such as a decrease in sex drive (libido) or impotence, were not reported as either a common or rare side effect with Zofran during these studies.
 
Yet, clinical trials are designed to factor out as many variables as possible in order to understand whether the medicine works and what its possible side effects are. This means that once the drug is approved, it is possible that new side effects may occur since a wider range of people are now taking the medicine and for longer periods of time. However, once a medicine is approved, a drug does not usually continue to be studied, so certain side effects that occur very rarely may never be documented, especially if it is not a serious side effect. For an individual person, it is difficult to say with complete assurance that a particular complaint is not due to a medicine, even though the complaint is not a reported side effect.
 
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