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Zofran Precautions and Warnings

There are several Zofran precautions and warnings to be aware of before starting the drug. For example, Zofran can interact with certain medications. Also, you should not take Zofran if you are allergic to any of the ingredients in Zofran. Prior to taking Zofran, you should talk to your healthcare provider about any health conditions you may have, such as liver problems, an arrhythmia, or phenylketonuria.

Zofran: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Zofran® (ondansetron hydrochloride) if you have:
  • Liver problems, including cirrhosis
  • An arrhythmia (an irregular heart rhythm), especially long QT syndrome
  • An electrolyte imbalance
  • Heart disease 
  • Phenylketonuria
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you:
  • Are pregnant or thinking of becoming pregnant (see Zofran During Pregnancy)
  • Are breastfeeding
  • Have severe or constant nausea or vomiting that is not helped by Zofran. Also talk with your healthcare provider if you are vomiting blood.
  • Have severe vomiting and diarrhea. This combination of problems can lead to dehydration and electrolyte imbalances.
It's important to also tell your healthcare provider about all of the medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
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