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Zofran Precautions and Warnings

Some Zofran Warnings and Precautions

Some Zofran warnings and precautions to be aware of include:
  • Zofran can interact with certain medications (see Zofran Drug Interactions).
  • Zofran is considered a pregnancy Category B medication. This means that Zofran is probably safe for use during pregnancy. However, because Zofran has not been studied in pregnant women, the full risks of using Zofran use during pregnancy are not known. Women who are pregnant should take Zofran only if the benefits of taking Zofran outweigh the risks to the developing baby. Be sure to discuss Zofran's possible risks and benefits with your healthcare provider before using Zofran during pregnancy (see Zofran During Pregnancy for more information).
  • It is not known if Zofran can pass through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about this. He or she can decide whether taking Zofran while nursing would be okay for your particular situation.
  • Zofran does not increase the activity or movement of the gastrointestinal tract and should not be used for this purpose. Using Zofran after abdominal surgery or chemotherapy may mask the symptoms of an intestinal blockage (abdominal ileus). Talk to your healthcare provider right away if you are severely constipated or have abdominal cramping or bloating, as this may be a sign of intestinal blockage.
  • In very rare cases, Zofran (especially the injectable version) can cause changes in heart rhythm, including a specific type of arrhythmia called QT prolongation. People with long QT syndrome should not take Zofran. People taking certain other medications, people with certain electrolyte balances, and people with heart disease may also be at an increased risk for QT prolongation with Zofran.


  • Zofran orally disintegrating tablets (ODTs) contain phenylalanine (less than 0.03 mg per tablet). This is important for people with phenylketonuria, as they must limit their intake of phenylalanine.
  • The dose of Zofran must be reduced in people will poor liver function. The maximum dose of Zofran for people with severe liver problems is 8 mg per day.
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