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Zofran for the prevention of vomiting and/or nausea after surgery (postoperative nausea and vomiting) has been examined in two studies. In these studies, people who took the drug one hour before anesthesia were less likely to have nausea and vomiting compared to people who did not take it. These studies involved women only, mainly because women are more likely to have nausea and vomiting after surgery.
Vomiting is usually much easier to prevent than nausea. Many of the studies of Zofran either did not look at nausea or did not show that it was effective for nausea.

When and How to Take Zofran

Some general considerations for when and how to take Zofran include the following:
  • The medication comes in several forms: tablets, orally disintegrating tablets (they dissolve in the mouth), and solution (a strawberry-flavored liquid). All of these forms are taken orally. Zofran also comes in an intravenous (IV) form your healthcare provider gives to you.
  • Zofran should be taken 30 minutes before the start of chemotherapy. Your healthcare provider may instruct you to take further doses after the first one.
  • The medication should be taken one to two hours before radiation. The dose after radiation depends on the type of radiation.
  • Zofran should be taken one hour before surgery begins.
  • Zofran can be taken with or without food.
  • The orally disintegrating tablets will quickly dissolve in your mouth, with no need for water. You should keep each tablet in its original blister pack until you need it. Do not try to push the tablet through the foil (the tablet is delicate and would be crushed). Instead, gently peel the foil away and remove the tablet.
  • For Zofran to work properly, it must be taken as prescribed. The medication will not work if you stop taking it.
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What Is Zofran?

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