Zofran® (
ondansetron hydrochloride) is a medication often prescribed to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. It comes in several different forms and strengths, including:
- 4 mg Zofran tablets
- 8 mg Zofran tablets
- 4 mg Zofran ODTs (orally disintegrating tablets)
- 8 mg Zofran ODTs (orally disintegrating tablets)
- Zofran oral solution 5 mg per 5 mL (one teaspoon)
- Zofran injection.
The recommended Zofran dose for preventing postoperative nausea and vomiting is 16 mg (either two 8 mg orally disintegrating tablets or regular tablets) taken one hour before anesthesia is administered.
For radiation-induced nausea and vomiting, dosing depends on the type of radiation (total body irradiation, single high-dose fraction radiotherapy, or daily fractionated radiotherapy).
The recommended dosage for high-risk chemotherapy is three 8 mg tablets, taken 30 minutes before chemotherapy. For medium-risk chemotherapy, the dose is 8 mg twice a day, taken 30 minutes before therapy, then eight hours after the first dose.
(Click Zofran Dosage for information on how Zofran dosing works for children, to learn about the warnings and precautions associated with this drug, and for more suggestions on when and how to take this medication.)
