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Zofran Drug Interactions

Zofran drug interactions with other medications, such as carbamazepine, phenytoin, or rifampicin, can decrease the level of Zofran in your blood. For most people, this interaction will not cause any problems and the doses of these drugs do not need to be adjusted. Be sure to talk to your healthcare provider or pharmacist about Zofran drug interactions that may apply to you.

An Overview of Zofran Drug Interactions

Zofran® (ondansetron hydrochloride) can potentially interact with many drugs. Some of the drugs that may lead to Zofran interactions include:
 

 

Zofran Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Zofran is combined with any of the drugs listed above.
 
Apomorphine
Due to the risk of dangerously low blood pressure (hypotension) and loss of consciousness, Zofran and apomorphine should not be combined.
  
Carbamazepine
Taking Zofran with carbamazepine can decrease the level of Zofran in your blood. For most people, this interaction will not cause any problems and the doses of these medications do not need to be adjusted.
 
QT-Prolonging Medications
There have been reports of a certain change in heart rhythm (known as QT prolongation) in people taking Zofran. This heart rhythm change can be dangerous. Check with your healthcare provider before combining Zofran with other QT-prolonging medications.
  
Phenytoin
Taking Zofran with phenytoin can decrease the level of Zofran in your blood. For most people, this interaction will not cause any problems and the doses of these medications do not need to be adjusted.
 

What Is Zofran?

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