Zofran Drug Interactions

Zofran drug interactions with other medications, such as carbamazepine, phenytoin, or rifampicin, can decrease the level of Zofran in your blood. For most people, this interaction will not cause any problems and the doses of these drugs do not need to be adjusted. Be sure to talk to your healthcare provider or pharmacist about Zofran drug interactions that may apply to you.

An Overview of Zofran Drug Interactions

Zofran® (ondansetron hydrochloride) can potentially interact with many drugs. Some of the drugs that may lead to Zofran interactions include:
 

Zofran Interactions Explained

Carbamazepine (Tegretol)
Taking Zofran with carbamazepine can decrease the level of Zofran in your blood. For most people, this interaction will not cause any problems and the doses of these medications do not need to be adjusted.
 
Phenytoin (Dilantin)
Taking Zofran with phenytoin can decrease the level of Zofran in your blood. For most people, this interaction will not cause any problems and the doses of these medications do not need to be adjusted.
 
Rifampicin (Rifadin)
Taking Zofran with rifampicin can decrease the level of Zofran in your blood. For most people, this interaction will not cause any problems and the doses of these medications do not need to be adjusted.
 
Tramadol (Ultram, Ultracet)
Taking Zofran with tramadol may increase your need for tramadol. Your healthcare provider may need to increase your dose of tramadol.
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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