Zofran Dosage

The dosage of Zofran will vary depending on whether it is used to prevent nausea and vomiting associated with chemotherapy, radiation, or surgery. The dosage will also vary on your age, other medical conditions you may have, and other medications you may currently be taking. In order for Zofran to work properly, you have to take it as prescribed.

An Overview of Zofran Dosing

The dose of Zofran® (ondansetron hydrochloride) your healthcare provider recommends will vary depending on a number of factors, including:
 
  • Your age
  • The medical condition you are being treated for
  • Other medical conditions you may have
  • Other medications you may currently be taking.
     
As is always the case, do not adjust your dosage unless your healthcare provider specifically instructs you to do so.
 

Zofran Dosing for Chemotherapy

The dose of Zofran depends on the type of chemotherapy -- high risk for nausea and vomiting or medium risk.
 
  • High-risk chemotherapy: The dose of Zofran for high-risk chemotherapy is Zofran 24 mg (taken as three 8 mg tablets) 30 minutes before chemotherapy.
     
  • Medium-risk chemotherapy: The dose of Zofran for medium-risk chemotherapy is Zofran 8 mg twice daily. The first dose should be taken 30 minutes before chemotherapy, and the second dose should be taken eight hours after the first dose. After that, Zofran should be taken twice a day (about every 12 hours) until one to two days after chemotherapy.
     
(Zofran Dosage Continued: Page 2)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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