Zofran and Hair Loss
There are a number of possible side effects with Zofran® (ondansetron hydrochloride). Hair loss, however, does not appear to be one of them.
Hair loss is a common side effect of chemotherapy or radiation treatments for cancer. If you are taking Zofran to prevent nausea or vomiting related to chemotherapy or radiation, it is very likely that the hair loss is due to the chemotherapy or radiation itself, not the Zofran.
If you experience hair loss while taking Zofran, talk with your healthcare provider. Depending on the severity of the hair loss, there are things that he or she may be able to do. If your symptoms continue to be bothersome or if your healthcare provider believes that the medicine is causing your hair loss, he or she may recommend trying another medicine to treat your condition.