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Zofran 8 mg Tablets

Zofran® (ondansetron hydrochloride) is a prescription medicine approved for the prevention of nausea and vomiting due to several causes.
Zofran Dosing for Surgery
The recommended Zofran dose for preventing postoperative nausea and vomiting is 16 mg (two 8 mg Zofran tablets) taken one hour before anesthesia is administered.
Zofran Dosing for Chemotherapy
The recommended dosage for high-risk chemotherapy is 24 mg (taken as three Zofran 8 mg tablets) 30 minutes before chemotherapy. For medium-risk chemotherapy, the usual dosage is 8 mg twice daily. The first dose should be taken 30 minutes before chemotherapy, and the second dose should be taken eight hours after the first dose. After that, Zofran should be taken twice a day (about every 12 hours) until one to two days after chemotherapy.
Zofran Dosing for Radiation
The dose of Zofran used for preventing radiation-induced nausea and vomiting depends on the type of radiation. People receiving total body irradiation may need to take 8 mg of Zofran one to two hours before radiotherapy, while those receiving daily fractionated radiotherapy to the abdomen start with 8 mg daily one to two hours before radiotherapy, followed by two more doses each day.
(Click Zofran Dosage for more detailed dosing guidelines, including tips for using this medication and information on how dosing works for children.)
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