Adult Zofran Dosage

Zofran® (ondansetron hydrochloride) is a medication commonly used for preventing nausea and vomiting before starting chemotherapy, surgery, or radiation therapy. It is available by prescription and comes in the form of tablets, orally disintegrating tablets, oral solution, and injection.
 
The recommended adult dosage of Zofran for preventing postoperative nausea and vomiting is two 8 mg tablets, taken one hour before anesthesia is administered. For radiation-induced nausea and vomiting, dosing will vary depending on the type of radiation; some types will require one 8 mg dosage, while others will require two to three additional doses.
 
The recommended Zofran dose for high-risk chemotherapy is three 8 mg tablets (taken all at once 30 minutes before chemotherapy), and the dose for medium-risk chemotherapy is 8 mg twice daily.
 
(Click Zofran Dosage for more information about dosing for adults, helpful tips and precautions for using this medication, and warnings associated with this drug.)
 
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;