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Ziv-Aflibercept Side Effects

As with other chemotherapy drugs, side effects are likely to occur with ziv-aflibercept. Clinical studies have shown that some of the most common reactions to this drug include fatigue, diarrhea, and weight loss. There are also potentially serious problems, such as infections, unusual bleeding, and liver damage, which should be reported to your healthcare provider right away.

An Introduction to Side Effects of Ziv-Aflibercept

Just like any medicine, ziv-aflibercept (Zaltrap®) can cause side effects. In fact, most people will experience some type of reaction to this drug, and some side effects can be quite significant. Talk to your healthcare provider about ways to prevent or lessen reactions to this medicine.
(This article covers many, but not all, of the possible side effects with ziv-aflibercept. Your healthcare provider can discuss a more complete list with you.)

Serious Ziv-Aflibercept Side Effects

Some side effects of ziv-aflibercept are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth, tongue, face, lips, or throat
    • Difficulty breathing or swallowing
  • Signs of infection, such as:
    • Fever
    • Chills
    • Body aches
    • Cough
    • Painful urination
  • Unusual bleeding or bruising
  • Black, tarry, or bloody stools
  • Blood in the urine
  • Coughing up blood
  • Sudden shortness of breath, chest pain, or cough
  • Pain, tenderness, or swelling in one arm or leg and not the other
  • Wounds or sores that do not heal
  • High blood pressure
  • Foamy urine
  • Swelling in the arms, hands, legs, ankles, or feet
  • Unexplained weight gain or weight loss
  • Persistent or severe diarrhea
  • Sudden severe headache
  • Difficulty speaking, talking, or walking
  • Blurred vision
  • Sudden numbness or weakness of the face, arm, or leg, especially on one side of the body
  • Severe abdominal (stomach) pain
  • Chest pain or pressure
  • Pain, redness, or swelling at the injection site
  • Sores, blisters, pain, or swelling in the mouth
  • Signs of liver problems, such as:
    • Yellowing of the skin or whites of the eyes (jaundice)
    • Dark urine
    • Pale stool
    • Upper-right abdominal (stomach) pain
  • Changes in the amount or how often you urinate
  • Redness, swelling, or pain on the palms of the hands or soles of the feet
  • Signs of a serious brain problem known as reversible posterior leukoencephalopathy, such as:
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Ziv-Aflibercept Medication Information

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