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Important Information for Your Healthcare Provider

Talk with your healthcare provider prior to receiving this medication if you have:
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Ziv-Aflibercept to learn more, including information on who should not receive this drug.)

How Does It Work?

Ziv-aflibercept is part of an antibody that is designed to bind to and block vascular endothelial growth factor (VEGF) and placental growth factor (PLGF). VEGF and PLGF are naturally occurring human proteins that stimulate the growth of new blood vessels. These blood vessels supply colorectal cancer tumors with nutrients.
By binding to VEGF and PLGF, ziv-aflibercept inhibits blood supply to the colorectal tumors, which can help to slow down tumor growth. However, this medication does not cure colorectal cancer.

Clinical Effects of Ziv-Aflibercept

In a clinical study, ziv-aflibercept was shown to help extend survival rates in people with metastatic colorectal cancer. In this study, people given ziv-aflibercept in combination with standard chemotherapy lived 13.5 months, on average, compared to 12.1 months for people receiving only standard chemotherapy.
In addition, those receiving ziv-aflibercept plus standard chemotherapy lived 6.9 months before their cancer started progressing (known as progression-free survival). The progression-free survival for people receiving just standard chemotherapy was 4.7 months.
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Ziv-Aflibercept Medication Information

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