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What Is Ziv-Aflibercept Used For?

How Does This Medicine Work?

Ziv-aflibercept is part of an antibody that is designed to bind to and block vascular endothelial growth factor (VEGF) and placental growth factor (PLGF). VEGF and PLGF are naturally occurring human proteins that stimulate the growth of new blood vessels. These blood vessels supply colorectal cancer tumors with nutrients.
By binding to VEGF and PLGF, ziv-aflibercept inhibits blood supply to the colorectal tumors, which can help to slow down tumor growth. However, this medication does not cure colorectal cancer.

Can Children Use It?

Ziv-aflibercept is not approved for use in children (usually defined as individuals younger than 18 years old), as it has not been adequately studied in this age group. Talk with your child's healthcare provider about the particular risks and benefits of using this medicine in children.

Is It Safe for Older Adults to Use Ziv-Aflibercept?

Older adults can use this medicine. However, clinical studies have shown that older adults are more likely than younger age groups to experience certain ziv-aflibercept side effects, such as:
  • Diarrhea
  • Dizziness
  • Loss of strength and energy
  • Weight loss
  • Dehydration.
Older adults who receive this medicine should be carefully monitored for diarrhea and dehydration.

What About Off-Label Ziv-Aflibercept Uses?

On occasion, your healthcare provider may recommend this medication for something other than the uses discussed in this article. This is called an "off-label" use. At this time, there are no well-accepted off-label uses for this medicine. Although ziv-aflibercept has been studied for the treatment of other types of cancer, including prostate, lung, and pancreatic cancer, it was found to be ineffective for these uses.
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Ziv-Aflibercept Medication Information

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