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Zevalin Dosage

When treating non-Hodgkin's lymphoma with Zevalin, the dosage will depend on your weight and platelet count. This medicine comes as an injection that is administered slowly into a vein through an intravenous infusion. It is given as a single dose within four hours after receiving a second dose of a medicine called rituximab.

An Introduction to Dosing With Zevalin

The dose of Zevalin® (ibritumomab) your healthcare provider recommends will vary, depending on your platelet count and your weight. As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Recommended Zevalin Dosage

Zevalin is used as part of a treatment regimen that includes rituximab (Rituxan®). On the first day of treatment, you will receive rituximab via an intravenous (IV) infusion (a slow drip into a vein). The dose of rituximab you receive will depend on your body surface area, which is calculated using your height and weight.
Six to eight days later (days seven, eight, or nine of the treatment regimen), you will receive your second dose of rituximab. Zevalin will be given within four hours of this second rituximab dose.
The Zevalin dosage is expressed in units of radioactivity, known as the Becquerel (Bq). The usual dose of Zevalin in people with a normal platelet count is 14.8 megabecquerel per kilogram body weight (MBq per kg), or about 6.7 MBq per pound. The dose should not exceed 1184 MBq, regardless of body weight.
The usual recommended dosage in people with a low platelet count is 11.1 MBq per kg (about 5 MBq per pound). People with an extremely low platelet count (less than 100,000 platelets per mm3) should not receive Zevalin.
You will be given other medications before receiving your dose of rituximab. This is known as "premedication." Premedication normally includes acetaminophen (Tylenol®) 650 mg and diphenhydramine (Benadryl® and others) 50 mg, taken by mouth. These medications are used to help limit the chance and severity of an infusion reaction (a potentially dangerous reaction that can occur from your dose).
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Zevalin Medication Information

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