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Xgeva

If you have cancer that has spread to the bones, your healthcare provider may prescribe Xgeva to help prevent certain skeletal problems. This medication can help prevent things like broken bones and pressure on the spinal cord. It is usually given by your healthcare provider and is injected just under the skin once every four weeks. Side effects include weakness, fatigue, and nausea.

What Is Xgeva?

Xgeva® (denosumab) is a prescription medication approved to prevent "skeletal-related events" in people with cancer that has spread to the bones. Skeletal-related events include broken bones, surgery to repair broken bones, radiation to relieve bone pain, or pressure on the spinal cord (spinal cord compression). Xgeva is given as an injection once a month.
 
(Click Xgeva Uses for more information on this topic, including possible off-label uses.)
 

Who Makes This Medication?

Xgeva is made by Amgen, Inc.
 

How Does Xgeva Work?

Xgeva is a manufactured antibody that is designed specifically to bind to a protein known as receptor activator of nuclear factor kappa-B ligand (RANKL). Xgeva prevents RANKL from activating the RANK receptor on the surface of osteoclast cells (as well as immature cells that will eventually become osteoclast cells). Osteoclasts are bone cells that are responsible for the breakdown of bone. These bone cells are more active in people with cancer that has spread to the bones.
 
Xgeva slows down the formation, activity, and survival of osteoclast cells, thus decreasing bone breakdown.
 
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Xgeva Injection Information

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