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Xgeva Side Effects

Seek medical treatment immediately if you are using Xgeva and develop serious side effects, such as confusion, shortness of breath, or jaw problems. Xgeva can cause other common problems, such as general weakness, nausea, or diarrhea. If you develop anything that doesn't seem right, contact your healthcare provider, as this drug can cause a number of potentially serious side effects.

An Introduction to Xgeva Side Effects

Just like any medicine, Xgeva® (denosumab) can cause side effects. However, not everyone who receives the drug will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
 
(This article covers many, but not all, of the possible side effects with Xgeva. Your healthcare provider can discuss a more complete list with you.)
 

Common Side Effects of Xgeva

Xgeva has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people receiving Xgeva were documented and compared to those that occurred in another group who were given zoledronic acid (another drug used for the same purpose). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared between the two groups.
 
In these studies, the most common Xgeva side effects included:
 
  • General weakness and/or fatigue -- in up to 45 percent of people
  • Low phosphate blood levels (hypophosphatemia) -- up to 32 percent
  • Nausea -- up to 31 percent
  • Shortness of breath -- up to 21 percent
  • Diarrhea -- up to 20 percent
  • Low blood calcium levels (hypocalcemia) -- up to 18 percent
  • Cough -- up to 15 percent
  • Headache -- up to 13 percent.
 
Some of these side effects are both common and potentially serious.
 
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