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Xgeva and Breastfeeding

Because it is unknown if Xgeva passes through breast milk, the manufacturer of the drug recommends that women not breastfeed while using Xgeva. However, it is thought that if the drug does pass through breast milk, it would be destroyed by the infant's digestive tract. If you are nursing, talk to your healthcare provider before using Xgeva.

Can Breastfeeding Women Use Xgeva?

At this time, it is not known whether Xgeva® (denosumab) passes through breast milk in humans. The manufacturer recommends that women avoid nursing while using the drug. However, you should talk with your healthcare provider before receiving Xgeva if you are breastfeeding or thinking about breastfeeding.
 

More Information on Xgeva and Breastfeeding

No studies have been conducted on whether Xgeva passes through breast milk in women. Even if the drug does pass through breast milk, it would probably be destroyed and inactivated by the infant's digestive system, as it is a delicate molecule that must be given by injection. However, until the medication has been shown to be safe for breastfeeding women and their infants, it may be a good idea to avoid nursing while using Xgeva.
 
In addition, studies in mice that were genetically modified in such a way as to mimic the action of Xgeva suggest that the medication could possibly interfere with the development of mammary glands and with lactation. It is possible that Xgeva could interfere with a woman's ability to breastfeed successfully.
 

Talking With Your Healthcare Provider

You should discuss breastfeeding and Xgeva use with your healthcare provider. Each woman's situation is different, and you and your healthcare provider understand your situation best. After considering what you want and expect, as well as your current health situation, the two of you can make a shared decision that is right for you.
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