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Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to taking vismodegib if you have:
  • Plans to donate blood or blood products
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Vismodegib to learn more, including information on who should not take the drug.)

How Does Vismodegib Work?

Vismodegib works by inhibiting what is known as the hedgehog pathway, a pathway that is active in signaling skin cancer cell growth. This drug blocks the hedgehog pathway by binding to a key protein in the pathway called the smoothened protein that activates other proteins involved in cell growth and survival. By binding to the smoothened protein, vismodegib prevents it from activating the other proteins, thus interfering with cancer cell growth and survival.

Clinical Effects

Vismodegib has been studied in people with locally advanced or metastatic basal cell carcinoma. In these studies, 43 percent of people whose skin cancer had advanced to nearby tissue experienced a complete or partial shrinkage of their lesions after treatment with vismodegib. In addition, 30 percent of those with metastatic cancer had a partial shrinkage of their lesions after treatment.
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Vismodegib Drug Information

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