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Drug Interactions With Vismodegib
Your healthcare provider needs to know if you take antidepressants, antacids, or certain other drugs before prescribing vismodegib. Interactions may occur if vismodegib is taken with medications such as these, which may decrease its effectiveness or increase your risk for side effects. To help minimize your risk for complications, make sure your healthcare provider knows about all medications, supplements, or vitamins you are taking.
Vismodegib (Erivedge™) can potentially react with a number of other medications. The drugs that can lead to interactions with vismodegib include but are not limited to:
- Antacids
- Certain antidepressants, such as:
- Amitriptyline (Elavil®)
- Citalopram (Celexa®)
- Clomipramine (Anafranil®)
- Fluoxetine (Prozac®, Sarafem®, Selfemra™)
- Imipramine (Tofranil®, Tofranil PM®)
- Certain medications used to treat diabetes, such as:
- Meglitinides, such as:
- Nateglinide (Starlix®)
- Repaglinide (Prandin®)
- Rosiglitazone (Avandia®)
- Sulfonylureas (or sulfonylurea combination medications), such as:
- Glimepiride (Amaryl®)
- Glimepiride and pioglitazone (Duetact®)
- Glimepiride and rosiglitazone (Avandaryl®)
- Glipizide (Glucotrol®, Glucotrol XL®)
- Glipizide and metformin (Metaglip®)
- Glyburide (DiaBeta®, Micronase®, Glynase®)
- Glyburide and metformin (Glucovance®)
- Tolbutamide (Orinase®)
- H2 blockers, such as:
- Cimetidine (Tagamet®)
- Famotidine (Pepcid®)
- Nizatidine (Axid®)
- Ranitidine (Zantac®)
- P-glycoprotein inducers, such as:
- Carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®)
- Dexamethasone (Decadron®)
- Doxorubicin (Adriamycin®, Doxil®)
- Nefazodone (Serzone®)
- Prazosin (Minipress®)
- Rifampin (Rifadin®)
- St. John's wort
- Tipranavir (Aptivus®)
- Trazodone (Desyrel®) and trazodone ER (Oleptro™)
- Vinblastine
- P-glycoprotein inhibitors, such as:
- Amiodarone (Cordarone®, Pacerone®)
- Atorvastatin (Lipitor®, also found in Caduet®)
- Carvedilol (Coreg®, Coreg CR®)
- Clarithromycin (Biaxin®)
- Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
- Darunavir (Prezista®)
- Dipyridamole (Persantine®, also found in Aggrenox®)
- Dronedarone (Multaq®)
- Erythromycin
- Grapefruit juice
- Itraconazole (Sporanox®)
- Ketoconazole (Nizoral®)
- Lapatinib (Tykerb®)
- Lopinavir and ritonavir (Kaletra®)
- Mefloquine (Lariam®)
- Nelfinavir (Viracept®)
- Nicardipine (Cardene®)
- Nilotinib (Tasigna®)
- Progesterone
- Propranolol (Inderal®, Inderal LA®, InnoPran XL®, also found in Inderide®)
- Quinidine
- Ranolazine (Ranexa®)
- Reserpine
- Ritonavir (Norvir®, also found in Kaletra®)
- Saquinavir (Invirase®)
- Sunitinib (Sutent®)
- Tacrolimus (Prograf®, Protopic®)
- Tamoxifen (Nolvadex®)
- Verapamil (Calan®, Calan SR®, Covera-HS®, Isoptin SR®, Verelan®, Verelan PM®)
- Propranolol (Inderal®, Inderal® LA, InnoPran XL™)
- Proton pump inhibitors (PPIs), such as:
- Dexlansoprazole (Dexilant™)
- Esomeprazole (Nexium®)
- Lansoprazole (Prevacid®, Prevacid® 24HR)
- Omeprazole (Prilosec®, Prilosec OTC®)
- Omeprazole and sodium bicarbonate (Zegerid®, Zegerid OTC®)
- Pantoprazole (Protonix®)
- Rabeprazole (AcipHex®)
Written by/reviewed by: Susan Lakey, PharmD, MPH, BCPP
Last reviewed by: Kristi Monson, PharmD