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Drug Interactions With Vismodegib

P-glycoprotein (Pgp) Inhibitors
P-glycoprotein is a protein found in the body. One of its roles is to help remove substances, such as medications, from the tissues in the body so they can be excreted through the urine or feces. Pgp helps remove vismodegib from the body, and certain medications called Pgp inhibitors decrease the activity of Pgp.
 
Thus, taking vismodegib with one of these drugs causes vismodegib to be removed more slowly, potentially increasing the amount of vismodegib in your body, which could increase your risk for side effects. Your healthcare provider may choose to monitor you more closely for side effects if you take these medications together.
 
Propranolol
Vismodegib could increase the level of propranolol in your bloodstream, potentially increasing your risk for side effects, such as low blood pressure and a low heart rate. Talk to your healthcare provider about this potential interaction if you take these drugs together.
 
Proton Pump Inhibitors
Taking a PPI with vismodegib may decrease the amount of vismodegib absorbed into your bloodstream, possibly decreasing its effectiveness. Talk to your healthcare provider before taking these medicines together.
 
Torsemide
Vismodegib may increase blood levels of torsemide, potentially increasing your risk for side effects. Talk to your healthcare provider about this potential interaction if you take these drugs together.
 

Final Thoughts

It is possible that not all drug interactions with vismodegib were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.
 
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Vismodegib Drug Information

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