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Drug Interactions With Vinorelbine

More Detail on Drug Interactions With Vinorelbine

The following sections explain in detail the potentially negative reactions that can occur when vinorelbine is combined with any of the drugs listed above.
 
Amphotericin B
Combining amphotericin B with anticancer medicines, including vinorelbine, may increase the risk for potentially serious amphotericin B side effects, such as kidney damage, low blood pressure (hypotension), and lung problems. Your healthcare provider may choose to monitor you more closely if you use these medicines together. 
 
Aripiprazole
Vinorelbine may increase the amount of aripiprazole in your body. If you use these medications together, let your healthcare provider know if you may be experiencing aripiprazole side effects
 
Biologic or Immunologic Medications
Using certain biologic or immunologic medicines with vinorelbine may increase the risk for potentially serious side effects, including infections and anemia. It is recommended that vinorelbine not be used in combination with some biologic or immunologic medicines, while other combinations will require dosage adjustments or close monitoring.
 
Cisplatin
Although these medicines are commonly used together, people who use vinorelbine with cisplatin are more likely to develop low white blood cell counts, which could increase the risk for potentially serious infections. If you use these medicines together, your healthcare provider will monitor your blood cell counts frequently. If your white blood cell levels become too low, your healthcare provider will reduce your dose of cisplatin or vinorelbine.
 
Clozapine
Using clozapine and vinorelbine together may cause extremely low white blood cell counts, increasing your risk for life-threatening infections. Talk to your healthcare provider about this potential interaction if you take clozapine. Do not stop taking clozapine unless your healthcare provider specifically tells you to do so.
 
CYP 3A4 Inducer Medications
The liver breaks down vinorelbine using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining vinorelbine with one of these drugs may decrease the level of vinorelbine in your body, potentially making it less effective.
 
CYP 3A4 Inhibitor Medications
The liver breaks down vinorelbine using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining vinorelbine with one of these drugs may increase the level of vinorelbine in your body, increasing your risk for side effects. 
 
Echinacea
Echinacea may decrease the effectiveness of vinorelbine. Do not take echinacea during vinorelbine treatment without your healthcare provider's approval.
 
Gefitinib
Combining gefitinib with vinorelbine may further increase the risk for abnormally low white blood cells. If you use these medicines together, your healthcare provider may need to monitor your blood cell counts more closely. 
 
Live Vaccinations
Live vaccines are vaccines that contain live viruses or bacteria. Like other chemotherapy medicines, vinorelbine makes you more susceptible to infections. Therefore, if you receive a live vaccine during vinorelbine treatment, you could become infected with the virus or bacteria used to make the vaccine.
 
Also, live vaccines may be less effective in people receiving chemotherapy, such as vinorelbine. Talk to your healthcare provider before receiving a vaccination during vinorelbine treatment.
 
Mitomycin
There have been reports of lung problems occurring in people taking mitomycin in combination with vinorelbine. Your healthcare provider may choose to monitor you more closely if you use these medications together. Let your healthcare provider know if you experience shortness of breath or difficulty breathing.
 
Paclitaxel
Combining paclitaxel and vinorelbine can increase the risk for nerve damage and nervous system side effects. Your healthcare provider will monitor you closely for symptoms of nerve problems if you are currently taking, or have recently taken, paclitaxel. Let your healthcare provider know if you experience numbness, tingling, or pricking sensations of the hands or feet, as these can be signs of nerve problems.
 
Pimozide
Vinorelbine may increase blood levels of pimozide, possibly increasing the risk for pimozide side effects. Talk to your healthcare provider about this potential interaction before using these medicines together.
 
Roflumilast
Combining roflumilast with vinorelbine may further increase your risk for developing infections. Talk to your healthcare provider about this potential interaction before using these medicines together.
 
Sipuleucel-T
Vinorelbine may decrease the effectiveness of sipuleucel-T. This is because sipuleucel-T is thought to work by stimulating the body's immune system, while vinorelbine decreases the activity of the immune system. Talk to your healthcare provider about this possible interaction before using these medicines together.
 
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Vinorelbine Drug Information

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