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Vincasar PFS Overdose

Some of the potential complications that may occur as a result of an overdose with Vincasar PFS (vincristine) include vomiting, seizures, and hallucinations. The specific effects, however, will depend on how much of the drug was used and a number of other factors. Treatment will likely involve administering certain medications and providing supportive care.


Can You Use Too Much Vincasar PFS?

Vincasar PFS® (vincristine sulfate) is a prescription medicine approved to treat people with certain types of cancer, including leukemia. This medication is given as an injection into a vein (an intravenous, or IV, injection).
Because Vincasar PFS is normally given by a healthcare provider in a healthcare setting, an intentional overdose is not likely to occur. However, as with most medicines, it is possible that an overdose could happen. For example, a miscalculation of the correct Vincasar PFS dose could result in too much of the drug being given.
The specific effects of an overdose would vary, depending on a number of factors, such as the Vincasar PFS dosage and whether it was combined with any other medications or substances.

Effects of an Overdose

Based on cases in which higher-than-recommended doses of Vincasar PFS were used to treat adults and children, symptoms of an overdose may include but are not limited to:
  • Numbness, tingling, pricking, or burning sensations in the hands or feet
  • Loss of hearing or vision
  • Decreased reflexes
  • Fever
  • Abdominal (stomach) pain and distention
  • Nausea and vomiting
  • Low white blood cell counts, which could increase the risk for infections
  • Low red blood cell counts (anemia)
  • Low platelet counts, which could increase the risk for bleeding
  • Constipation
  • Sores in the mouth and throat
  • High blood pressure (hypertension)
  • Low blood pressure (hypotension)
  • Muscle pain
  • Bone pain
  • Face, jaw, or neck pain
  • Muscle weakness
  • An inability to urinate
  • Diarrhea
  • Agitation
  • Insomnia
  • Hallucinations (seeing or hearing things that are not real)
  • Delusions (believing things that are not true)
  • Confusion
  • Seizures
  • Coma
  • Death.
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