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Vincasar PFS Drug Interactions

Vincasar PFS Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Vincasar PFS is combined with any of the drugs listed above.
 
Amphotericin B
Combining amphotericin B with chemotherapy medicines, such as Vincasar PFS, may increase the risk for amphotericin B side effects, such as kidney damage, low blood pressure (hypotension), and lung problems. Your healthcare provider may choose to monitor you more closely if you use these medicines together. 
 
Aripiprazole
Vincasar PFS may increase blood levels of aripiprazole, potentially increasing your risk for aripiprazole side effects. Let your healthcare provider know if you think you may be experiencing problems with aripiprazole. He or she may choose to adjust your dose.  
 
Certain Biologic and Immunologic Medications
Using Vincasar PFS with certain biologic and immunologic medications could increase your risk for certain side effects, including low blood cell counts and infections. It is recommended that Vincasar PFS not be used in combination with some biologic and immunologic medicines, while other combinations will require careful monitoring or dosage adjustments.
 
Clozapine
Taking clozapine with Vincasar PFS may increase your risk for dangerously low levels of white blood cells, which could make you more susceptible to potentially serious infections. It is generally recommended that clozapine not be taken with other medicines that can lower white blood cell counts, such as Vincasar PFS. However, it is important that you not stop taking clozapine unless your healthcare provider specifically tells you to do so.
 
CYP 3A4 Inducer Medications
The liver breaks down Vincasar PFS using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining Vincasar PFS with one of these drugs may decrease the level of Vincasar PFS in your body, potentially making it less effective. Talk to your healthcare provider about this potential interaction before using these medicines together.
 
CYP 3A4 Inhibitor Medications
The liver breaks down Vincasar PFS using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining Vincasar PFS with one of these drugs may increase the level of Vincasar PFS in your body, increasing your risk for side effects. Your healthcare provider may need to monitor you more closely if you combine these medications.  
 
Digoxin
Vincasar PFS may decrease the amount of digoxin absorbed into your body from your gastrointestinal (GI) tract, which could decrease your digoxin blood levels. This interaction is thought to only occur with digoxin tablets rather than other forms of digoxin. Your healthcare provider may choose to monitor your response to digoxin more closely if you use these medicines together and adjust your dose if needed.
 
Echinacea
Vincasar PFS may be less effective if used in combination with echinacea. Do not take echinacea during chemotherapy treatment without first speaking with your healthcare provider.
 
Live Vaccinations
Live vaccines contain live viruses or bacteria. If you receive a live vaccine during Vincasar PFS treatment, you could become infected with the virus or bacteria from the vaccine. Also, live vaccines may be less effective in people using Vincasar PFS.
 
In general, people who are undergoing chemotherapy are advised to not receive a live vaccination. Talk to your healthcare provider before receiving a vaccination or immunization during Vincasar PFS treatment, and for three months after your last dose.
 
Mitomycin
Breathing problems have been reported in people using vinca alkaloid anticancer medicines, such as Vincasar PFS, in combination with mitomycin. Your healthcare provider may need to monitor you for lung problems if you use these medicines together. Let your healthcare provider know if you have shortness of breath or any difficulty breathing.
 
MAOIs
Both MAOIs and Vincasar PFS can cause orthostatic hypotension (low blood pressure that occurs when you stand up from sitting or lying down). Using these medicines together can further increase your risk for this side effect. Orthostatic hypotension can cause you to feel dizzy, faint, or fall down. If you combine Vincasar with an MAOI, make sure to sit or stand slowly, and let your healthcare provider know if you feel particularly dizzy or faint.
 
Nifedipine
Nifedipine has been reported to increase blood levels of Vincasar PFS; however, the significance of this interaction is unknown. If you use these drugs together, your healthcare provider may choose to monitor you more closely for Vincasar PFS side effects.
 
P-glycoprotein (Pgp) Inducers
P-glycoprotein is a protein found in the body. One of its roles is to help remove substances, such as medications, from the tissues in the body so they can be removed through the urine or feces. Pgp helps remove Vincasar PFS from the body.
 
Certain other medications (known as Pgp inducers) increase the activity of Pgp. Combining Vincasar PFS with one of these Pgp inducers causes Vincasar PFS to be removed from the body too quickly, potentially making it less effective. Talk to your healthcare provider about this potential interaction if you take a Pgp inducer.
 
P-glycoprotein (Pgp) Inhibitors
P-glycoprotein is a protein found in the body. One of its roles is to help remove substances, such as medications, from the tissues in the body so they can be excreted through the urine or feces. Pgp helps remove Vincasar PFS from the body.
 
Medications known as Pgp inhibitors can decrease the activity of Pgp. Thus, using Vincasar PFS with one of these drugs causes Vincasar PFS to be removed more slowly, increasing your risk for side effects. Talk to your healthcare provider about this potential interaction if you take a Pgp inhibitor.
 
Phenytoin and Fosphenytoin
Vincasar PFS may decrease blood levels of phenytoin and fosphenytoin, which could make the medications less effective. In addition, phenytoin and fosphenytoin may decrease blood levels of Vincasar PFS. Talk to your healthcare provider about this potential interaction if you will be using these drugs together.
 
Pimozide
Vincasar PFS may increase blood levels of pimozide, potentially increasing your risk for pimozide side effects. In general, these medicines should not be used together if at all possible. Talk to your healthcare provider about this potential interaction before using Vincasar PFS with pimozide.
 
Roflumilast
Combining roflumilast with Vincasar PFS may further increase your risk for developing infections. Talk to your healthcare provider about this potential interaction before using these drugs together.
 
Sipuleucel-T
Vincasar PFS could decrease the effectiveness of sipuleucel-T. This is because sipuleucel-T is thought to work by stimulating the body's immune system, while Vincasar PFS decreases the activity of the immune system. Talk to your healthcare provider about this possible interaction before using these medicines together.
 
Warfarin
Vincasar PFS may increase or decrease the effects of warfarin. If you use these medicines together, your healthcare provider may need to test your prothrombin time ("protime," or PT) and international normalized ratio (INR) more closely than usual and adjust your warfarin dosage if needed.
 
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