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Drug Interactions With Vemurafenib

P-glycoprotein (Pgp) Inducers
P-glycoprotein is a natural protein that helps remove substances, such as medications, from the tissues in the body, so they can be excreted through the urine or feces. Pgp helps remove vemurafenib from the body. Certain medications known as Pgp inducers increase the activity of Pgp.
 
Taking vemurafenib with one of these Pgp inducers causes vemurafenib to be removed from the body more quickly, potentially decreasing vemurafenib blood levels. This could make vemurafenib less effective. Your healthcare provider may choose to monitor you more closely if you take vemurafenib with a Pgp inducer.
 
P-glycoprotein (Pgp) Inhibitors
P-glycoprotein is a natural protein that helps remove substances, such as medications, from the tissues in the body, so they can be excreted through the urine or feces. Pgp helps remove vemurafenib from the body. Certain medications known as Pgp inhibitors decrease the activity of Pgp.
 
Taking vemurafenib with one of these Pgp inhibitors causes vemurafenib to be removed from the body more slowly, potentially increasing vemurafenib blood levels and increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely for side effects if you take vemurafenib with a Pgp inhibitor.
 
Propranolol
Vemurafenib may increase the level of propranolol in your body, potentially increasing your risk for propranolol side effects. Your healthcare provider may choose to monitor your blood pressure and heart rate, and decrease your propranolol dose if needed, if you take these medications together.
 
Rasagiline
Vemurafenib may increase the amount of rasagiline in your blood, which could increase the risk for rasagiline side effects. Talk to your healthcare provider about this potential interaction before taking these medicines together.
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Vemurafenib Drug Information

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