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Trexall Warnings and Precautions

If you have chronic liver disease, you should not take Trexall. Warnings and precautions also apply to people with a weakened immune system and women who are pregnant or breastfeeding. To help ensure a safe, effective treatment process, make sure your healthcare knows if you have any other medical conditions or any allergies.

What Should I Tell My Healthcare Provider Before Taking Trexall?

Prior to taking Trexall™ (methotrexate), talk to your healthcare provider if you have:
  • A weakened immune system due to HIV, AIDS, or various other causes
  • Low blood cell counts of any type, such as anemia or low platelets
  • Liver disease, such as cirrhosis, hepatitis, or liver failure
  • Alcoholism
  • Plans to receive radiation treatments
  • Any allergies, including to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Be sure to tell your healthcare provider about all other medicines you may be taking, including prescription and nonprescription medications, vitamins, and herbal supplements.

Specific Precautions and Warnings for Trexall

Precautions and warnings to be aware of prior to taking Trexall include the following:
  • Trexall is considered a pregnancy Category X medicine, which means it presents a clear risk of harm to the fetus (see Methotrexate and Pregnancy for more information). Women should use appropriate birth control while taking this drug and should not attempt to get pregnant until a full menstrual cycle after stopping the medication. Men should not try to conceive a child for at least three months after stopping Trexall.
  • Trexall is a powerful medication capable of producing significant toxicity. It should be reserved for treating severe diseases in people who have already tried less toxic treatment alternatives.
  • All people taking Trexall must be closely and regularly monitored. This may include various tests, such as blood tests to check liver and kidney function, chest x-rays, and even periodic liver biopsies. Frequent blood tests to check blood cell counts are also necessary.
  • This medication can cause liver fibrosis and cirrhosis, especially with long-term use.
  • Trexall can cause serious lung problems. Let your healthcare provider know if you develop a dry cough and/or shortness of breath.
  • In rare cases, this medicine can cause serious skin reactions that may involve a potentially disfiguring or fatal loss of skin tissue. Let your healthcare provider know if you develop any unexplained rash while taking Trexall.
  • Low blood cell counts due to Trexall can be quite dangerous. Depending on the type, such problems can increase the risk of dangerous infections or life-threatening bleeding.
  • Taking this drug while receiving radiation treatments may increase the risk of tissue and bone damage.
  • Trexall may sometimes cause lymphoma (a type of cancer), which will sometimes go away once treatment is stopped.
  • This medicine passes through breast milk and could cause serious problems in a nursing child. Therefore, if you are breastfeeding, check with your healthcare provider before taking Trexall (see Methotrexate and Breastfeeding).
  • Trexall can interact with certain medications (see Trexall Drug Interactions).
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Trexall Medication Information

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