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Trexall Side Effects

Because Trexall is a powerful medication, it has the potential to cause serious side effects, including frequent infections, lung damage, and severe mouth sores. In fact, its use is typically reserved for severe cases in which a person has not responded to other medications. To help ensure your safety, tell your doctor if you develop any side effects while taking Trexall.

An Introduction to Trexall Side Effects

As with any medicine, side effects are possible with Trexall™ (methotrexate). This is a powerful medication that can cause significant and sometimes serious side effects. For this reason, it is usually reserved for treating severe diseases in cases where other treatments have failed or are not appropriate.
(This article covers many, but not all, of the possible side effects with Trexall. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Trexall

Trexall is a relatively old medication. As is common with older medications, the prescribing information for Trexall lists only vague information about possible side effects, without including much information about specific percentages.
According to this limited information, some of the most common side effects seen with Trexall include:
  • Low white blood cell counts (as measured by a blood test)
  • High liver enzymes (as measured by a blood test)
  • Nausea and vomiting
  • "Abdominal distress" (presumably digestive upset)
  • Mouth sores (such as canker sores)
  • Fever
  • Dizziness
  • A general ill feeling
  • Excessive fatigue
  • Chills
  • Frequent or severe infections.
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Trexall Medication Information

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