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Trametinib Side Effects

Some of the possible side effects of trametinib include diarrhea, a rash, and swelling. Studies have shown that many people who use this drug will develop some type of reaction. Because trametinib is associated with potentially serious problems, such as vision problems and unusual bleeding, let your healthcare provider know immediately if you develop something that doesn't seem right.


An Introduction to Side Effects of Trametinib

As with other anticancer medications, trametinib (Mekinist™) can cause side effects, some of which can be significant. Although not everyone who takes the medication will have problems, many people will experience some type of side effect during trametinib treatment. Talk to your healthcare provider about ways you can manage some of the more common trametinib side effects.
(This article covers many, but not all, of the possible side effects with trametinib. Your healthcare provider can discuss a more complete list with you.)

Serious Trametinib Side Effects

Some trametinib side effects are potentially serious and should be reported to your healthcare provider immediately. Signs of these potential reactions include but are not limited to:
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling, especially of the mouth, lips, or throat
    • Wheezing
    • Difficulty breathing or swallowing
  • Any rash, even if not accompanied by other symptoms (since the medication can cause dangerous problems that start with a rash)
  • Signs of a blood clot in the arms, legs, or lungs, such as shortness of breath, chest pain, or arm or leg swelling
  • Signs of heart problems, such as:
    • Swelling in the legs, ankles, or feet
    • A sudden, unexplained weight gain
    • An irregular, fast, or forceful heartbeat
    • Lightheadedness, dizziness, or fainting
    • Shortness of breath
  • Changes in vision, such as:
    • Blurred vision
    • Loss of vision
    • Seeing halos
    • Seeing colored dots
  • New or worsening shortness of breath or cough
  • Any redness, swelling, peeling, sores, or rash on the skin, hands, or feet
  • High blood sugar
  • Any new skin malignancies or tumors anywhere on the body
  • A fever (as this can be the start of a very serious reaction)
  • High blood pressure
  • Abnormal bleeding or bruising
  • Extreme tiredness or fatigue
  • Any unusual muscle pain.
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Trametinib Drug Information

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