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Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to taking this medication if you have:
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Trametinib to learn more, including information on who should not take the drug.)

How Does It Work?

Trametinib belongs to a broad group of medicines known as kinase inhibitors. More specifically, it is a MEK inhibitor. MEK stands for mitogen-activated extracellular signal regulated kinase. It is a protein that is involved in telling cells to grow and multiply. Trametinib blocks the action of MEK and thus helps to stop or slow down the growth of cancer cells, which can slow down the progression of melanoma.

Clinical Effects of Trametinib

In a clinical study, trametinib delayed the progression of cancer in people with melanoma that had spread to other areas of the body (metastasized) or could not be treated with surgery. All the people in the trial also had a mutation (abnormal change) in a gene known as the BRAF gene.
In the study, people were randomly assigned to receive trametinib or a chemotherapy medication (either dacarbazine or paclitaxel). Those given trametinib had 4.8 months of treatment before their melanoma progressed further, while those given chemotherapy had a progression of their melanoma after only 1.5 months of treatment.
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Trametinib Drug Information

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