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Precautions and Warnings With Trametinib

If you have lung disease, any eye conditions, or certain other medical issues, tell your healthcare provider before taking trametinib. In some people, this drug may cause heart problems, vision problems, or other potentially dangerous complications. Trametinib also carries warnings and precautions for women who are pregnant or nursing.


What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking trametinib (Mekinist™) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Trametinib Precautions and Warnings

Some warnings and precautions to be aware of prior to taking this medication include the following:
  • Even though trametinib is used to treat malignant melanoma, it may actually increase the risk of other cancers, including skin cancers and nonskin cancers.
  • This drug may increase the risk of bleeding, including dangerous internal bleeding. Alert your healthcare provider to any unusual bleeding or bruising.
  • Trametinib may increase the risk of blood clots in the arms, legs, or lungs. Seek immediate medical attention if you have signs of a blood clot, such as unexplained arm or leg pain or shortness of breath.
  • This medication can cause serious fevers. Sometimes, these fevers are accompanied by serious problems, such as low blood pressure, dehydration, and kidney failure. Make sure to let your doctor know right away if you develop a fever while taking trametinib.
  • Trametinib has been reported to cause heart problems, including heart failure. Your healthcare provider will assess how well your heart is functioning before you start taking trametinib, one month after you start treatment, and then every two to three months during treatment. If you start to develop heart problems, you will need to stop taking trametinib at least temporarily. In some cases, you may need to stop taking the medicine altogether.
  • Trametinib may cause potentially serious eye problems, which could lead to loss of vision. Let your healthcare provider know right away if you have any changes in your sight, such as:
    • Blurred vision
    • Loss of vision
    • Seeing colored dots
    • Seeing halos around objects.
  • Some people taking trametinib have developed lung problems, including inflammation and scarring of the lungs. In some cases, the problems were serious enough to require a hospital stay. Let your healthcare provider know if you develop a new or worsening cough or shortness of breath during treatment. Your healthcare provider may recommend you stop treatment, at least temporarily, while you are being evaluated for potentially serious lung problems.  
  • Skin reactions, including redness, acne, and skin rash, were commonly reported during trametinib clinical trials. In some cases, the problem was severe, led to infections, or required treatment in the hospital. Let your healthcare provider know if you develop any abnormal skin reactions during treatment, such as:
    • Redness
    • A rash
    • Acne
    • Tenderness and peeling of the hands or feet.
  • You may develop high blood pressure (hypertension) during trametinib treatment or, if you already have high blood pressure, it may get worse. Therefore, your healthcare provider will check your blood pressure periodically during treatment.
  • Trametinib is a pregnancy Category D medication, which means it may harm an unborn child (see Mekinist and Pregnancy).
  • It is not known whether trametinib passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Mekinist and Breastfeeding).
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