Drug Interactions With Tramadol ER

Several medications can cause tramadol ER drug interactions, including most antidepressants, sleep medications, and digoxin. Some of these interactions could increase your risk of serious side effects, such as hallucinations, muscle spasms, and difficulty breathing. To reduce the risk of drug interactions, talk to your healthcare provider about any other medications you are taking (including non-prescription medications).

Tramadol ER Drug Information

Drug Interactions With Tramadol ER: An Overview

Tramadol ER (Ultram^® ER, Ryzolt^™) is a long-acting prescription pain medication. It can potentially interact with a number of other medications, particularly other medications that cause sedation or affect serotonin levels (an important neurotransmitter). Some of the medicines that may lead to drug interactions with tramadol ER include, but are not limited to:

Alcoholic beverages
Carbamazepine (Carbatrol^®, Epitol^®, Equetro^®, Tegretol^®)
Cyclobenzaprine (Flexeril^®, Amrix^®)
Dextromethorphan (a common active ingredient in cough medications)
Digoxin (Digitek^®, Lanoxin^®)
Linezolid (Zyvox^®)
Other medications that cause drowsiness, including, but not limited to:

Antipsychotic medications
Anxiety medications
Most antidepressants
Narcotic pain relievers
Sleep medications
Some antihistamines

Promethazine (Phenadoz^™, Phenergan^®, Promethegan^™)
Quinidine
Sibutramine (Meridia^®)
St. John's wort
Triptans, including:

Tryptophan
Warfarin (Coumadin^®, Jantoven^®).

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