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Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to taking this medication if you have:
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • Kidney disease, such as kidney failure (renal failure)
  • Been previously treated with thioguanine or a medication known as mercaptopurine (Purinethol®)
  • Been told you have thiopurine-S-methyltransferase (TPMT) deficiency or a defect in the TPMT gene
  • Plans to receive a vaccination
  • Plans for surgery or dental work
  • An infection
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Thioguanine for more information, including details on who should not take the drug.)

Clinical Effects of Thioguanine

In studies, thioguanine has been shown to help people with AML achieve remission when used as part of combination treatment. In one study, 59 percent of children with AML who had not been previously treated went into remission when given thioguanine in combination with other medicines, including prednisone, cytarabine (DepoCyt®), cyclophosphamide (Cytoxan®), and vincristine (Vincasar PFS®). The children stayed in remission for about 11.5 months.
In another study, 53 percent of adults with AML who had not received previous treatment achieved remission when given thioguanine in combination with cytarabine. Remission lasted about 8.8 months.
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Thioguanine Drug Information

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