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Drug Interactions With Thioguanine

More Detail on Drug Interactions With Thioguanine

The following sections explain in detail the potentially negative reactions that can occur when thioguanine is combined with any of the drugs listed above.
5-ASA Derivatives
5-ASA derivatives may increase the risk for potentially serious thioguanine side effects, especially in people with a certain genetic (inherited) risk factor that causes low levels of an enzyme known as thiopurine methyltransferase (TPMT). Your healthcare provider can check you for a TPMT deficiency, if needed. You may need a lower thioguanine dose.
Amphotericin B
Combining amphotericin B with chemotherapy medicines, such as thioguanine, may increase the risk for amphotericin B side effects, such as kidney damage, low blood pressure (hypotension), and lung problems. Your healthcare provider may choose to monitor you more closely if you take these medicines together. 
Certain Biologic and Immunologic Medications
Taking thioguanine with other medicines that suppress the immune system, such as certain biologic and immunologic medications, could increase your risk for low blood cell counts, which may cause infections, anemia, and bleeding problems. It is recommended that thioguanine not be used in combination with some biologic and immunologic medicines, while other combinations will require careful monitoring or dosage adjustments.
Taking clozapine with thioguanine may increase the risk for dangerously low white blood cells, and potentially life-threatening infections. It is generally recommended that these medicines not be taken together. However, do not stop taking clozapine unless your healthcare provider specifically tells you to do so.
Thioguanine may be less effective when taken with echinacea. Do not take echinacea during thioguanine treatment without first discussing it with your healthcare provider.  
Live Vaccinations
Live vaccines are vaccines that contain live viruses or bacteria. If you receive a live vaccine while taking thioguanine, you might become infected with the virus or bacteria from the vaccine. Also, live vaccines may be less effective in people taking thioguanine.
In general, people on chemotherapy are advised to not receive live vaccines. Talk to your healthcare provider before receiving a vaccination or immunization during thioguanine treatment, and for three months after your last dose.
Combining roflumilast with thioguanine may further increase your risk for developing infections. Talk to your healthcare provider about this potential interaction before taking these medicines together.
Thioguanine could decrease the effectiveness of sipuleucel-T. This is because sipuleucel-T is thought to work by stimulating the body's immune system, while thioguanine decreases the activity of the immune system. Talk to your healthcare provider about this possible interaction before taking these medicines together.
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Thioguanine Drug Information

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