Before prescribing a specific temsirolimus dosage, your healthcare provider will take into consideration other medications you are taking and your liver function. This medication comes as an injection that is given intravenously (IV) once a week by your healthcare provider. People who do not have liver problems will generally require 25 mg of temsirolimus weekly, while those who have liver problems may need a lower amount.
The dose of temsirolimus (Torisel®) your healthcare provider recommends will vary, depending on a number of factors, including:
- Your liver function
- Other medications you are taking.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
The standard dose of temsirolimus for treating advanced renal cell carcinoma (kidney cancer) is 25 mg once a week. The recommended dose in people with mild liver disease is 15 mg once a week.
People taking certain other medicines may receive higher or lower temsirolimus doses (see Drug Interactions With Temsirolimus). Also, people who experience certain potentially serious temsirolimus side effects may be given a lower dose. However, it is generally recommended that the dosage be no lower than 15 mg each week.
Your healthcare provider will likely give you an intravenous (IV) antihistamine medication, such as diphenhydramine (Benadryl®, Sominex®, or many others), about 30 minutes before you receive temsirolimus. This is to help reduce the chance of an allergic reaction to temsirolimus. Allergic reactions are possible with any dosage, even if you have received temsirolimus before without any problems.