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Drug Interactions With Temsirolimus

Denosumab
Taking denosumab with temsirolimus could increase your risk for potentially serious infections. Talk to your healthcare provider before taking these medicines together. Also, contact your healthcare provider if you develop any signs of infection, such as fever, chills, aches and pains, or coughing.
 
Echinacea
Echinacea could decrease the effectiveness of temsirolimus. Do not take echinacea while receiving temsirolimus without first speaking with your healthcare provider.
 
Leflunomide
Combining leflunomide with temsirolimus may increase your risk for blood cell problems, such as abnormally low red blood cells, white blood cells, and platelets. Your healthcare provider will need to monitor you more closely for these problems if you take these medications together.
 
Live Vaccinations
Live vaccines are vaccines that contain live viruses or bacteria. If you receive a live vaccine while receiving temsirolimus, you might become infected with the virus or bacteria from the vaccine. Also, live vaccines may be less effective in people undergoing temsirolimus treatment. Talk to your healthcare provider before receiving a vaccination or immunization while receiving this medication.
 
Medications That Thin the Blood (Anticoagulant Medications)
Temsirolimus can increase the risk for bleeding in the brain. Anticoagulants further increase this risk. Talk to your healthcare provider about this interaction before combining temsirolimus with medications that thin the blood.
 
Natalizumab
Combining temsirolimus with natalizumab may increase your risk for developing infections, including potentially serious infections. Do not take these medicines together unless your healthcare provider tells you otherwise.
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Temsirolimus Drug Information

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