As a type of chemotherapy drug, Temodar is used to prevent cancer cells from growing and multiplying. It is specifically approved for the treatment of certain brain tumors known as anaplastic astrocytoma and glioblastoma multiforme. The drug comes as a capsule or an injection that is given slowly into a vein. Side effects are common and can include fatigue, hair loss, and vomiting.
What Is Temodar?Temodar® (temozolomide) is a prescription medication approved to treat certain types of cancerous brain tumors. Specifically, it is used to treat tumors known as anaplastic astrocytoma and glioblastoma multiforme. Temodar may be used alone or in combination with radiation treatment.
Who Makes This Medication?Temodar capsules are made by Merck Sharp & Dohme, Corp., a subsidiary of Merck & Co., Inc. Temodar for injection is made by Baxter Oncology GmbH for Merck Sharp & Dohme, Corp.
Clinical Effects of TemodarIn clinical studies, Temodar was shown to improve survival in people with certain types of brain tumors. In studies of people with glioblastoma multiforme, a group of people received Temodar and radiation, while another group received radiation treatment alone. In this study, people who received Temodar and radiation therapy lived about 2.5 months longer than those treated with just radiation therapy.
In another study, which included people with anaplastic astrocytoma that had worsened despite other treatment, about 22 percent of people were said to respond to treatment with Temodar. The median duration of response was 50 weeks, which means over half of the people continued to respond to the medicine for at least 50 weeks. Approximately 65 percent of those treated were still alive after 12 months of treatment.