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Drug Interactions

Sorafenib may react with a number of other medicines (see Drug Interactions With Sorafenib).

What If I Overdose on This Medicine?

An overdose of this medicine can cause diarrhea and skin reactions, such as a rash. Seek immediate medical attention if you or someone else may have taken too much.
(Click Nexavar Overdose for more information.)

What If I Miss a Dose of Sorafenib?

If you miss a dose of sorafenib, simply skip it and take your next dose at the usual time. Do not take a double dose.

How Does This Medicine Work?

Sorafenib belongs to a class of medications known as multikinase inhibitors. It works by blocking the action of kinases, which are proteins in the body that cause cells (including cancer cells) to grow and multiply. By blocking signals that kinases send to cells telling them to grow, sorafenib helps slow down the progression of cancer.

Clinical Effects

In a clinical study, sorafenib slowed down the growth and spread of cancer in people with advanced kidney cancer. In this study, kidney cancer did not get worse for an average of 5.5 months in people who took this drug, compared with 2.8 months in people who did not.
Sorafenib has also been shown to slow down the growth of liver cancer and extend survival in people with the disease. In a clinical study, people given sorafenib survived, on average, 10.7 months on treatment, compared with 7.9 months for people not given it.
Another clinical study showed a slowed growth of thyroid cancer. People taking sorafenib survived an average of 10.8 months with no progression (without the cancer getting worse), compared to 5.8 months for those not taking the drug.
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Sorafenib Drug Information

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