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Sorafenib Dosage

The recommended dosage of sorafenib for treating certain types of kidney, liver, and thyroid cancer is usually 400 mg taken twice daily. However, if you develop serious side effects during treatment, you may need to take a lower dosage or even stop treatment. This chemotherapy drug comes as a tablet and should be taken on an empty stomach, at least one hour before or two hours after food.

An Introduction to Your Dosage of Sorafenib

The dose of sorafenib (Nexavar®) your healthcare provider recommends will vary, depending on how well you tolerate the medication. As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Sorafenib Dosing Guidelines

The standard dose of sorafenib for the treatment of renal cell carcinoma (a type of kidney cancer), hepatocellular carcinoma (a type of liver cancer), or differentiated thyroid carcinoma (a type of thyroid cancer) is 400 mg twice daily. Treatment usually continues until sorafenib is no longer working to slow down the progression of cancer or until potentially serious side effects occur.
People who experience certain potentially serious side effects may need to stop taking sorafenib for some time, or take a lower dose. If a lower amount is necessary, sorafenib is usually reduced to 400 mg once daily. If side effects continue, the dosage may be reduced again to 400 mg every other day.

General Information on Taking Sorafenib

Some considerations to keep in mind during treatment with sorafenib include the following:
  • This medication comes in tablet form. It is usually taken by mouth twice a day.
  • Sorafenib should be taken on an empty stomach at least one hour before or two hours after food.
  • Swallow the tablet whole with a glass of water. Do not split, crush, or cut the tablets.
  • Try to take your dosages at the same time each day to keep an even level of the drug in your bloodstream.
  • For sorafenib to work properly, it must be taken as prescribed.
  • If you are unsure about anything related to dosing with sorafenib, please talk with your healthcare provider, nurse, or pharmacist.
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Sorafenib Drug Information

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