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Drug Interactions With Sorafenib

Echinacea can make sorafenib less effective. Do not take these products together unless your healthcare provider tells you otherwise.
Combining leflunomide and sorafenib may increase your risk for blood cell problems, including abnormally low red blood cells, white blood cells, and platelets. These problems could increase your risk for anemia, infections, and bleeding problems. Your healthcare provider may choose to monitor you more closely if you take these medications together.
Live Vaccinations
Live vaccines contain live viruses or bacteria. If you receive a live vaccine while taking sorafenib, you might become infected with the virus or bacteria from the vaccine. Also, live vaccines may be less effective in people taking sorafenib. Talk to your healthcare provider before receiving a vaccination or immunization while taking this medication.
QT-Prolonging Medications
Sorafenib can cause a certain change in the heart rhythm known as QT prolongation. Taking sorafenib with other drugs that may cause QT prolongation can increase your risk for this potentially life-threatening problem. Your healthcare provider may need to monitor you for this if you take these medicines together.
Combining sorafenib with natalizumab may increase your risk for developing infections, including potentially serious infections. It is generally recommended that these medications not be taken together.
Neomycin may decrease blood levels of sorafenib, potentially making it less effective. Talk to your healthcare provider about this potential interaction before taking these drugs together.
People who have a certain type of lung cancer and are being treated with paclitaxel and carboplatin should not take sorafenib due to the possible increased risk of death when all three medications are used together.
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