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Drug Interactions With Sorafenib

More Detail on Drug Interactions With Sorafenib

The following sections explain in detail the potentially negative interactions that can occur when sorafenib is combined with any of the drugs listed above.
 
Acetaminophen
Taking acetaminophen during sorafenib treatment may increase your risk for liver damage. It is generally recommended that people who take sorafenib limit their use of acetaminophen. Talk to your healthcare provider about how much acetaminophen you can safely take each day during sorafenib treatment.
 
Carboplatin
People who have a certain type of lung cancer and are being treated with carboplatin and paclitaxel should not take sorafenib due to the possible increased risk of death when all three medications are taken together.
 
CYP 3A4 Inducer Medications
The liver breaks down sorafenib using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining sorafenib with one of these drugs may decrease the level of sorafenib in your body, potentially making it less effective. It is generally recommended that sorafenib not be combined with strong CYP 3A4 inducers.
 
CYP 3A4 Inhibitor Medications
The liver breaks down sorafenib using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining sorafenib with one of these drugs may increase the level of sorafenib in your body, potentially increasing your risk for side effects.
 
Denosumab
Taking denosumab with sorafenib could increase your risk for potentially serious infections. Talk to your healthcare provider before taking these medicines together. Also, contact your healthcare provider if you develop any symptoms of an infection, such as:
 
  • Fever
  • Chills
  • Aches and pains
  • Coughing.
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Sorafenib Drug Information

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