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Sancuso Uses

Sancuso is used to prevent nausea and vomiting due to chemotherapy. This prescription medication comes in the form of a patch, which is applied to the skin 24 to 48 hours before the start of chemotherapy. It is worn for no more than seven days total. Possible off-label Sancuso uses may include preventing nausea and vomiting due to other causes, such as radiation or pregnancy.

What Is Sancuso Used For?

Sancuso® (granisetron transdermal) is a prescription medication approved to help prevent nausea and vomiting due to certain chemotherapy regimens that last five days or less. It comes as a skin patch that is applied 24 to 48 hours before the start of the chemotherapy regimen, and is worn until at least 24 hours after the last day of chemotherapy (for up to seven days total).
Nausea and vomiting are common side effects of chemotherapy (see Chemotherapy and Nausea). They are likely due to many causes. Some types of chemotherapy are more likely to cause nausea and vomiting than others. Sancuso is approved to prevent nausea and vomiting due to chemotherapy regimens that are moderately likely or highly likely to cause vomiting.
It is much easier to prevent nausea and vomiting before it happens, rather than to treat it once it starts. Sancuso is licensed to prevent nausea and vomiting, but is not a treatment for these things once they start.

How Does It Work?

Nausea and vomiting are complex processes involving many chemicals in the body and several parts of the body, including the brain and the small intestine. It is likely that Sancuso works in the small intestine, but it may also work in the brain.
The medication works by blocking serotonin, a chemical produced by the body that is associated with nausea and vomiting. Serotonin has many effects in the body and has several receptors where it can bind. It blocks serotonin at a specific type of receptor (the 5-HT3 receptor), which is important for nausea and vomiting. Sancuso has no effects on other types of serotonin receptors in the body.
Sancuso comes in the form of a skin patch. The medication is absorbed through the skin into the bloodstream. It provides around-the-clock medication, helping to prevent nausea and vomiting without the need for swallowing capsules or tablets (which can be difficult for people fighting nausea and vomiting).
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