Your individual romidepsin dosage will primarily depend on your height and weight. If you develop intolerable or serious side effects, you may need to temporarily stop the medicine and restart it at a lower amount. This drug is administered intravenously by a healthcare provider. Each dose takes about four hours and is given once a week for three weeks, followed by a short break.
The dose of romidepsin (Istodax®) your healthcare provider recommends will vary, based on a number of factors, including:
- Your height and weight
- How you tolerate the medication.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
The usual recommended dosage of romidepsin for treating T-cell lymphoma is based on your body surface area, which is calculated using your height and weight. Doses are normally given on days 1, 8, and 15 of a 28-day cycle. The cycle will be repeated as long as the medicine is working and is not causing serious side effects.
If you do experience serious side effects, treatment will be stopped until the side effects improve. Your healthcare provider will then determine if you should restart romidepsin at the same dose or a lower amount. In some cases, your healthcare provider may recommend you stop using the medicine altogether.
Some considerations to keep in mind during treatment with romidepsin include the following:
- Romidepsin is given as a slow injection into a vein (an intravenous, or IV, infusion) over a four-hour period.
- The injection will be given by a healthcare provider in a healthcare setting, such as a hospital or clinic.
- Doses are usually given about a week apart for three doses, followed by a short break, for a 28-day treatment cycle.
- Romidepsin should be inspected before use and should not be given if it contains particles or is discolored.
- For the medication to work properly, it must be used as prescribed. It is important to keep your appointments to receive your romidepsin doses.
- If you are unsure about anything related to your dosage or romidepsin dosing in general, please talk to your healthcare provider or pharmacist.