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Drug Interactions With Romidepsin

You may not be able to take St. John's wort or drink grapefruit juice while undergoing treatment with romidepsin. Negative drug interactions can occur when it is combined with these and various other products, possibly increasing your risk for dangerous reactions or decreasing the effectiveness of the medications. To help ensure a safe treatment, tell your healthcare provider about all medications, vitamins, and herbal supplements you are taking.

An Overview of Romidepsin Interactions

Romidepsin (Istodax®) may react with a number of other products. Some of the drugs that can interact with romidepsin include but are not limited to:
  • CYP 3A4 inducer medications, such as:
  • CYP 3A4 inhibitor medications, such as:
  • Medications that cause a certain change in the heart rhythm known as QT prolongation (see QT-Prolonging Medications for a list of such drugs)
  • P-glycoprotein inducers, such as:
  • P-glycoprotein inhibitors, such as:
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Romidepsin Drug Information

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