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Drug Interactions With Romidepsin

P-glycoprotein (Pgp) Inhibitors
P-glycoprotein is a protein in the body that helps remove substances, such as medications, from the tissues in the body so they can be excreted through the urine or feces. Pgp helps remove romidepsin from the body, and medications known as Pgp inhibitors decrease the activity of Pgp.
 
Combining romidepsin with one of these Pgp inhibitors causes the drug to be removed more slowly, potentially increasing the amount of romidepsin in your body and increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely for side effects if you combine these drugs.
 
Warfarin
Romidepsin has been reported to prolong the prothrombin time ("protime" or PT) and increase the international normalized ratio (INR) in people taking warfarin, which indicates there may be an increased risk for bleeding problems. Your healthcare provider may choose to monitor your PT/INR more closely if you use these medicines together and lower your warfarin dosage if necessary.
 

Final Thoughts

It is possible that not all romidepsin drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.
 
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Romidepsin Drug Information

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