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Regorafenib Side Effects

Research has shown that a majority of people taking regorafenib are likely to experience some type of side effect with this chemotherapy drug. Some of the most commonly reported reactions include weakness, diarrhea, and voice changes. There are also potentially dangerous problems, such as infections, seizures, and high fevers, which should be reported to your healthcare provider right away.

An Introduction to Side Effects of Regorafenib

Just like any medicine, regorafenib (Stivarga®) can cause side effects. In fact, most people will experience some type of reaction to this drug, and some side effects of regorafenib can be quite significant. Talk to your healthcare provider about ways to prevent or lessen reactions to this medicine.
(This article covers many, but not all, of the possible side effects with regorafenib. Your healthcare provider can discuss a more complete list with you.)

Serious Regorafenib Side Effects

Some side effects of regorafenib are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth, tongue, face, lips, or throat
    • Difficulty breathing or swallowing
  • Signs of infection, such as:
    • Fever
    • Chills
    • Body aches
    • Cough
    • Painful urination
  • Signs of anemia, such as:
    • Weakness
    • Fatigue
    • Shortness of breath
    • Pale skin
  • Unusual bleeding or bruising
  • Black, tarry, or bloody stools
  • Vomiting blood, or vomit that looks like coffee grounds
  • Blood in the urine, which could look like pink, brown, or red urine
  • Frequent nosebleeds
  • Heavy menstrual bleeding
  • Coughing up blood
  • Redness, pain, blisters, bleeding, or swelling on the palms of the hands or soles of the feet
  • High blood pressure (hypertension)
  • Changes in vision
  • Severe headaches
  • Seizures
  • Confusion
  • Chest pain, shortness of breath, dizziness, or feel like you might pass out
  • Severe abdominal (stomach) pain, swelling, tenderness
  • High fever
  • Wounds that do not heal or heal slowly
  • Persistent or severe diarrhea, nausea, or vomiting
  • Sores, blisters, pain, or swelling in the mouth or throat
  • Signs of dehydration, such as:
    • Dry mouth
    • Decreased urination
    • Feeling thirsty
    • Sleepiness
  • Signs of liver problems, such as:
    • Yellowing of the skin or whites of the eyes (jaundice)
    • Dark urine
    • Pale stool
    • Upper-right abdominal (stomach) pain.
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Regorafenib Drug Information

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