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Rasburicase Side Effects

When rasburicase was given to people during clinical trials, some of the most common reactions included nausea, headaches, and swelling. Fortunately, many people who use this medicine tolerate it fairly well. Serious side effects with rasburicase are possible, however, and may include problems like fever, allergic reactions, and yellowing of the whites of the eyes or skin.

An Introduction to Side Effects of Rasburicase

Just like any medicine, rasburicase (Elitek®) can cause side effects. However, not everyone who uses the medication will experience problems. In fact, many people tolerate it quite well. If reactions do occur, in most cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with rasburicase. Your healthcare provider can discuss a more complete list with you.)

Serious Rasburicase Side Effects

Some side effects of rasburicase are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Pain, redness, swelling, or irritation at the injection site
  • Yellowing of the skin or whites of the eyes (jaundice)
  • Pain in the upper abdomen (stomach)
  • Swelling or sores on the inside of the mouth or throat
  • Swelling of the arms, hands, legs, ankles, or feet
  • Coughing up blood
  • Difficulty breathing
  • Shortness of breath
  • Chest pain or tightness
  • A rapid or irregular heartbeat
  • Lightheadedness, dizziness, or fainting
  • Weakness
  • Confusion
  • Headache
  • Fatigue
  • Fever and chills
  • Cold, clammy skin
  • Pale, grey, or bluish color to the skin
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling, especially of the mouth, lips, or throat
    • Wheezing
    • Difficulty breathing or swallowing.
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