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Rasburicase

Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to receiving this medication if you have:
 
  • A medical condition known as glucose-6-phosphate dehydrogenase (G6PD) deficiency
  • Developed a reaction to rasburicase treatment in the past
  • Been told you have cytochrome b5 reductase (also known as methemoglobin reductase) deficiency
  • Any allergies, including to foods, dyes, or preservatives.
 
Also, let your healthcare provider know if you are:
   
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 
(Click Precautions and Warnings With Rasburicase to learn more, including information on who should not use the drug.)
 

How Does It Work?

Uric acid is a chemical that forms when the body breaks down substances known as purines. When cancer cells are destroyed by chemotherapy, they may release purines and other substances into the body. When the body breaks down these purines, uric acid levels can increase and cause problems.  
 
Rasburicase is an enzyme called urate oxidase (an enzyme is a protein that starts a chemical reaction). Urate oxidase causes a reaction that converts uric acid into an inactive form that is easier for the body to excrete. This can help lower uric acid levels or prevent uric acid levels from increasing in the first place. 
 
Urate oxidase is not naturally found in humans. Instead, rasburicase is made from a genetically altered strain of yeast. 
 
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